UGT2B4 allele nomenclature (view change log)

Allele naming	Protein	Nucleotide change	Amino acid change	Effect	Enzyme activity		Genbank	Reference	Notes
					In vivo	In vitro
UGT2B4*1a	UGT2B4.1			Wild-type	Normal	Normal	Y00317^1; AJ005162	Jackson MR et al
UGT2B4*1b	UGT2B4.1	IVS4+61(T>C)					N/A	Saeki et al
UGT2B4*1c	UGT2B4.1	-1255(A>C)/-162(T>G)/IVS4+61(T>C)					N/A	Saeki et al
UGT2B4*1d	UGT2B4.1	IVS4+161_162(ins TGATAA)/1212(A>T)	A^404A	Silent			N/A	Saeki et al
UGT2B4*1e	UGT2B4.1	-1255(A>C)/-162(T>G)/IVS3-13_6(delT)/IVS5-83(G>C)					N/A	Saeki et al
UGT2B4*1f	UGT2B4.1	IVS4+61(T>C)/IVS4+146(G>A)					N/A	Saeki et al
UGT2B4*1g	UGT2B4.1	-1255(A>C)/-162(T>G)/IVS4+61(T>C)/ IVS4+146(G>A)					N/A	Saeki et al
UGT2B4*1h	UGT2B4.1	-162(T>G)/IVS4+61(T>C)					N/A	Saeki et al
UGT2B4*1j	UGT2B4.1	IVS4+145(C>T)/IVS4+161_162(ins TGATAA)					N/A	Saeki et al
UGT2B4*1k	UGT2B4.1	-1255(A>C)/-162(T>G)/IVS4+161_162(ins TGATAA)					N/A	Saeki et al
UGT2B4*1l	UGT2B4.1	-1255(A>C)/-162(T>G)/IVS5-83(G>C)					N/A	Saeki et al
UGT2B4*1m	UGT2B4.1	-1255(A>C)/-162(T>G)/IVS3-13_6(delT)					N/A	Saeki et al
UGT2B4*1n	UGT2B4.1	-162(T>G)/IVS4+146(G>A)/IVS4+161_162(ins TGATAA)/Exon5+1212(A>T)	A^404A	Silent			N/A	Saeki et al
UGT2B4*1p	UGT2B4.1	IVS4+145(C>T)/IVS4+161_162(ins TGATAA)/1212(A>T)	A^404A	Silent			N/A	Saeki et al
UGT2B4*1q	UGT2B4.1	1212(A>T)/IVS5-83(G>C)	A^404A	Silent			N/A	Saeki et al
UGT2B4*1r	UGT2B4.1	IVS4+161_162(ins TGATAA)					NT_077444.2	Saeki et al	Renamed from UGT1A6*1a
UGT2B4*1s	UGT2B4.1	IVS5-83(G>C)					N/A	Saeki et al	Renamed from UGT1A6*1i^2
UGT2B4*1t	UGT2B4.1	IVS2+44(C>T)/IVS4+61(T>C)					N/A	Saeki et al	Renamed from UGT1A6*1o^2
UGT2B4*2a	UGT2B4.2	1374(T>A)/1375(C>A)	D^458E		Normal (Levesque E et al)		AF064200	Levesque E et al
UGT2B4*2b	UGT2B4.2	-1255(A>C)/-162(T>G)/IVS4+61(T>C)/IVS4+109_114(delATAAAA)/IVS5-52(C>T)/1374(T>A)/1375(C>A)	D^458E/R^459R				N/A	Saeki et al	Renamed from UGT2B4*2a
UGT2B4*3	UGT2B4.3	325(T>C)/1186(T>C)	F^109L/F^369L		No activity with hyodeoxycholic acid (Jin CJ et al)		AF081793	Jin CJ et al	Formerly UGT2B11
UGT2B4*4	UGT2B4.4	IVS4+162_163(ins TGATAA)/1364(A>G)	K^455R				N/A	Saeki et al	Named *455R by the author
UGT2B4*5	UGT2B4.5	IVS4+162_163(ins TGATAA)/1212(A>T)/1531(T>C)	A^404A/C^511R				N/A	Saeki et al	Named *511R by the author
UGT2B4*6	UGT2B4.6	1372(G>C)/1374(T>A)	D^458Q				N/A	Riedy M et al

¹ Y00317 has been resequenced and shown to be identical to AJ005162. See the Levesque et al paper or the alignment for details.

² Alleles were renamed since the letters “i” and “o” are excluded in the UGT Allele Nomenclature because of indexing problems.

N/A : data not available in the manuscript