UGT1A8 allele nomenclature (view change log)

 

Allele naming

Protein

Nucleotide change

Amino acid change

Effect

Enzyme activity

Genbank

References

Notes

In vivo

In vitro

UGT1A8*1a

 

UGT1A8.1

 

 

Wild-type

 

Normal

Normal

AF462268

 

 

UGT1A8*1b

 

UGT1A8.1

765(A>G)

T255T

Silent

 

 

N/A

Huang et al. 2002

Renamed from *1a

UGT1A8*2

 

UGT1A8.2

518(C>G)

A173G

 

 

Similar to *1

(Huang et al. 2002; Bernard et al. 2004)

AF462267

Huang et al. 2002

 

UGT1A8*3

 

UGT1A8.3

830(G>A)

C277Y

 

 

Severely reduced

(Huang et al. 2002; Bernard et al. 2004)

N/A

Huang et al. 2002

 

 

N/A : data not available in the manuscript