UGT1A10
allele nomenclature (view change log)
Allele naming |
Protein |
Nucleotide change |
Amino acid change |
Effect |
Enzyme activity |
Genbank |
Reference |
Notes |
|
In vivo |
In vitro |
||||||||
UGT1A10*1a |
UGT1A10.1 |
|
|
Wild-type |
|
Normal |
|
|
|
UGT1A10*1b |
UGT1A10.1 |
126(G>A) |
Q42Q |
|
|
|
N/A |
Renamed
from UGT1A10*1a |
|
UGT1A10*1c |
UGT1A10.1 |
597(T>C) |
H199H |
|
|
|
N/A |
Renamed
from UGT1A10*1b |
|
UGT1A10*1d |
UGT1A10.1 |
597(T>C)/693(C>T) |
H199H/A231A |
|
|
|
N/A |
Renamed
from UGT1A10*1c |
|
UGT1A10*2a |
UGT1A10.2 |
415(G>A) |
E139K |
|
|
|
N/A |
|
|
UGT1A10*3a |
UGT1A10.3 |
719(C>T) |
T240M |
|
|
|
N/A |
|
|
UGT1A10*3b |
UGT1A10.3 |
693(C>T)/
719(C>T) |
A231A/T240M |
|
|
|
N/A |
Renamed
from UGT1A10*3a |
|
UGT1A10*4a |
UGT1A10.4 |
730(C>A) |
L244I |
|
|
|
N/A |
|
|
UGT1A10*4b |
UGT1A10.4 |
693(C>T)/
730(C>A) |
A231A/L244I |
|
|
|
N/A |
Renamed
from UGT1A10*4a |
|
UGT1A10*4c |
UGT1A10.4 |
597(T>C)/
693(C>T)/730(C>A) |
H199H/
A231A/L244I |
|
|
|
N/A |
Renamed
from UGT1A10*4b |
|
UGT1A10*5 |
UGT1A10.5 |
177(G>A) |
M59I |
|
|
No
change |
N/A |
|
|
UGT1A10*6 |
UGT1A10.6 |
605(C>T) |
T202I |
|
|
Reduced by 50% |
N/A |
|
|
UGT1A10*7 |
UGT1A10.7 |
622 (T>C) |
I211T |
|
|
No activity |
N/A |
|
N/A : Data not available in the manuscript.