Welcome to the Pharmacogenomics Laboratory web site.
Research themes: Improving drug treatments and prognostic tools
Recent Lab News
http://louisville.edu/envirome/fii-workshop-2020
First Integrated International Workshop: Acetyltransferases, Sulfotransferases, and UDP-Glucuronosyltransferases (FII Workshop 2020)
Dates: April 1-3, 2020
09.2019
Dr Eric Lévesque was awarded a Prostate Cancer Canada Discovery grant for his project entitled The Contribution of Non-Classical 11-oxy Androgens to Prostate Cancer Progression. This research will be conducted in collaboration with Prof. Chantal Guillemette and Dr Louis Lacombe.
Most recent work by Adrien Labriet, Ph.D. student, was published in Scientific Reports. The publication entitled Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients was conducted in collaboration with the research group of Dr Giuseppe Toffoli, CRO Aviano, Italy.
Welcome to Sophie Tremblay, a new M.Sc. student in the Pharmacogenomics lab.
08.2019
Dr Chantal Guillemette received a highly competitive Fondation grant for her research program entitled Functional pharmacogenomics of cancer: from mechanisms to personalized therapy
Congratulations to Adrien Labriet, Ph.D. student, for being awarded 1st prize for Best talk by a Ph.D. student at the Journée scientifique des étudiants, Cancer Research Center
07.2019
A new publication for Eric Allain, Ph.D. student, in collaboration with the CLL research group of Professor Katrina Vanura, Medical University of Vienna: Inactivation of Prostaglandin E2 as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia published in Frontiers in Oncology. Congratulations to all.
06.2019
Congratulations to Adrien Labriet, Ph.D. student, who was awarded 1st prize for Best poster presentation by a Ph.D. student at the Journée de la recherche, CHU de Québec for his presentation entitled Combination of germline variations in FOLFIRI pharmacogenetics pathways associated with survival in metastatic colorectal cancer.
04.2019
Great news for Eric Allain, Ph.D. student: Eric was awarded a highly competitive Graduate student scholarship from the Fonds de recherche du Québec – Santé (FRQS) to pursue his Ph.D. project. Way to go Eric!
02.2019
Welcome to Vincent Bat, a new M.Sc. student in the Pharmacogenomics lab under the supervision of Dr Guillemette.
Congratulations to Dr Eric Lévesque and Prof. Chantal Guillemette for their publication on the PROCURE cohort in collaboration with the groups of Drs Louis Lacombe, Yves Fradet, Armen Aprikian, Fred Saad and Simone Chevalier in Cancer Epidemiology and Biomarkers Prevention entitled A Comprehensive Analysis of Steroid Hormones and Progression of Localized High-Risk Prostate Cancer.
Jean-Philippe Emond, M.Sc. and resident MD student, published his first paper entitled Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibodyin Drug Metabolism and Disposition. This work was conducted under the supervision of Dr Eric Lévesque and Prof. Chantal Guillemette and in collaboration with the research groups of Dr Louis Lacombe and Prof. Phil Smith (University of North Carolina, USA) and Uli Zanger (University of Tübingen, Tübingen, Germany).
This paper is featured on the May 2019 edition of the journal. Congratulations to all for the great work!
12.2018
Congratulations to Adrien Labriet, Ph.D. student, for his 2nd prize for best oral presentation by a Ph.D. student for his talk given at the Scientific day of the Endo-Nephro Research Axis.
Patrick Caron and Véronique Turcotte, chemists, published with Dr Guillemette and Lévesque their novel validated method to quantify Abiraterone metabolites in plasma samples of prostate cancer patients. The paper, entitled An LC-MS/MS method for quantification of abiraterone, its active metabolites D(4)-abiraterone (D4A) and 5α-abiraterone, and their inactive glucuronide derivatives, was published in the Journal of Chromatography B. Great piece of work!
11.2018
Congratulations to the research trainees in the Guillemette group who were honored at the Research day of the Faculty of Pharmacy. Adrien Labriet, Ph.D. student, 1st prize for best oral presentation by a Ph.D. student Eric Allain, Ph.D. student, 1st prize for best poster presentation by a Ph.D. student
09.2018
Welcome to Jean-Philippe Emond, resident MD student and M.Sc. student, who joined the Pharmacogenomics lab under the supervision of Dr Lévesque and Guillemette.
08.2018
An excellent track record for research trainees in the Guillemette group at the Research Day of the Cancer Research Center
Yannick Audet-Delage, Ph.D. student, 1st prize for Best poster presentation by a Ph.D. student
Adrien Labriet, Ph.D. student, 3rd prize for Best talk by a Ph.D. student
Joanie Vaillancourt, M.Sc. student, Best poster presentation by an M.Sc. student
07.2018
Adrien Labriet, Ph.D. student, presented his most recent work at the 22nd ISSX North American meeting in Montréal, Canada. Adrien’s project was selected for an oral presentation, entitled RPL28 promoter polymorphism rs4806668 is associated with reduced survival in FOLFIRI-treated metastatic colorectal cancer patients.
Congratulations to Prof. Chantal Guillemette and Dr Eric Lévesque for their publication in collaboration with the group of Drs Paul Toren and Lawrence Klotz in Clinical Cancer Research entitled Serum sex steroids as prognostic biomarkers in patients receiving androgen deprivation therapy for recurrent prostate cancer: a post-hoc analysis of the PR.7 trial.
05.2018
Eric Allain, Ph.D. student, published his first paper on his Ph.D. project in Annals of Hematology entitled: Sex-dependent association of circulating sex steroids, pituitary hormones and treatment-free survival in patients with chronic lymphocytic leukemia. This study was conducted in collaboration with the research team of Prof. Katrina Vanura, Medical University of Vienna, Austria.
Eric also presented his work at the AACR Annual meeting 2018, held in Chicago.
Congratulations to Patrick Caron, chemist, and Chantal Guillemette for their work in collaboration with Michael B. Cook’s team, NIH, published in the Journal of the National Cancer Institute entitled Associations between Prediagnostic Levels of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma.
04.2018
Great news for Adrien Labriet, Ph.D. student: Adrien was awarded a highly competitive Graduate student scholarship from the Fonds de recherche du Québec – Santé (FRQS) to pursue his Ph.D. project. Congratulations!
Adrien‘s work on colorectal cancer conducted in collaboration with the group of Dr Giuseppe Toffoli, CRO Aviano, Italy, was published in Frontiers in Pharmacology, entitled: Association of STAT-3 rs1053004 and VDR rs11574077 with FOLFIRI-related gastrointestinal toxicity in metastatic colorectal cancer patients.
Congratulations to Yannick Audet-Delage, Ph.D. student: Yannick received a travel award from the Metabolomics Society to attend the AACR annual meeting 2018.
Yannick presented his recent work at the AACR, entitled Metabolomics biomarkers for endometrial cancer and its recurrence after surgery in postmenopausal women.
This study was also published in Frontiers in Endocrinology, 9:87
Yannick also published in the Journal of Steroids and Biological Molecular Biology a second paper on his work on endometrial cancer entitled Estradiol Metabolites as Biomarkers of Endometrial Cancer Prognosis After Surgery.
Very well done Yannick!
03.2018
Joanie Vaillancourt, M.Sc. student, was awarded a Hydro-Québec excellence scholarship, for the Faculty of Pharmacy. Good news Joanie!
02.2018
The Guillemette’s group published novel findings on alternative variants of the main hepatic UGT2B10. Congratulations to Adrien Labriet, PhD student, and colleagues for their publication Posttranscriptional regulation of UGT2B10 hepatic expression and activity by alternative splicing in Drug Metabolism and Disposition.